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The end of the pandemic? Pfizer’s new COVID pill cuts hospitalizations and deaths by 90% in high-risk people – HotAir

Posted on 11/06/2021 By TCT Admin No Comments on The end of the pandemic? Pfizer’s new COVID pill cuts hospitalizations and deaths by 90% in high-risk people – HotAir
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Is this it?

I wrote yesterday that vaccine approval for teenagers aged 5 to 11 plus the massacre in blue states on Tuesday evening has the skilled class all of a sudden questioning if it’s time to declare the pandemic over. From a scientific standpoint, the nuclear weapon in opposition to infectious illness — vaccination — has now been virtually absolutely deployed throughout the inhabitants. From a political standpoint, the affiliation of Democrats with protracted oppressive COVID restrictions like college closings is killing the social gathering at the polls.

Suddenly they’re in search of an exit. But they want a approach to talk to Americans, particularly risk-averse lefties, that it’s now protected to return to normalcy. Or as protected because it’s going to be for the subsequent few years as America adjusts to the actuality of endemic COVID.

And so I repeat the query: Is this it?

The arrival of a fantastically efficient therapeutic portends a new period in which COVID isn’t deadly for anybody, even people previously at excessive threat of loss of life as a result of underlying situations. We already had excellent news on that entrance a couple of weeks in the past when Merck introduced that its new antiviral, molnupiravir, reduce hospitalizations and deaths in high-risk people by 50 p.c in trials. That wasn’t fairly as efficient as monoclonal antibodies however the antibody remedy is given through IV. It’s costly and requires care from knowledgeable. Molnupiravir is a pill and a course of remedy prices solely a 3rd of what the antibodies do. Eventually it might be accessible at each drug retailer in America, able to be distributed as quickly as somebody checks optimistic. Hospitalizations and deaths would plummet if everybody who wanted it might get it.

Today’s information from Pfizer improves significantly on the excellent news from Merck. Their new antiviral pill, paxlovid, was 90 p.c efficient in trials in opposition to hospitalization for high-risk people, higher than even monoclonal antibodies. Conceivably a cocktail of therapeutics that features paxlovid might be simpler nonetheless. We’re on the cusp, it appears, of turning COVID’s loss of life price into one thing extra akin to the flu’s.

So is that this it? The end of the pandemic?

The work on Pfizer’s antiviral drug, known as paxlovid, constructed off efforts by Pfizer scientists to develop therapies for the outbreak of extreme acute respiratory syndrome (SARS) almost twenty years in the past. Paxlovid combines a new molecule designed by Pfizer scientists in July 2020 and ritonavir, an antiviral drug used to deal with HIV.

In a scientific trial, individuals at excessive threat of growing extreme sickness got the drug routine — a mix of three capsules, taken twice a day — inside three days of their covid-19 signs starting. Half obtained the experimental drug and half obtained a placebo. Paxlovid was 89 p.c efficient in lowering threat of hospitalization and loss of life. Among 389 people who obtained the drug, three hospitalizations and no deaths have been reported. Among 385 people who bought a placebo, 27 hospitalizations have been reported, with seven subsequent deaths…

The drug additionally gave the impression to be efficient even at 5 days after signs started. For about 600 people who obtained the drug inside 5 days of signs, six people have been hospitalized. Among the 600 who obtained a placebo, there have been 41 hospitalizations and 10 subsequent deaths.

“We were hoping that we had something extraordinary, but it’s rare that you see great drugs come through with almost 90% efficacy and 100% protection for death,” stated Pfizer’s chief scientific officer afterward. Let me emphasize once more that these weren’t garden-variety wholesome younger COVID sufferers. The topics have been at excessive threat as a result of numerous comorbidities like weight problems, diabetes, and so on. And nonetheless — zero deaths amongst those that obtained paxlovid, even those that didn’t begin remedy till 5 days after their first signs.

How does it work? Differently from Merck’s drug, it seems. Molnupiravir “hacks” the virus by scrambling its genetic code, however some recipients are destined to fret that it’d trigger cell mutations too. Paxlovid is a protease inhibitor. Protease is an enzyme in cells {that a} virus exploits to assist it replicate inside the physique by “cutting” strands of proteins to type new viral molecules. Pfizer’s drug prevents the slicing from occurring. Protease inhibitors have additionally labored magic in combating HIV and Hepatitis C. Now they’re a miracle treatment for COVID too.

And Pfizer’s already experimenting with cocktails. Per the WSJ, “Adding ritonavir helps slow the breakdown of the Pfizer drug, extending its duration to help fight the virus, according to the company.”

Scott Gottlieb is a member of Pfizer’s board so he has a bottom-line cause to tout the drug, however I feel his evaluation right here is true. This is the starting of the end of the pandemic. Watch, then learn on:

“The end of the pandemic at least as it relates to the United States is in sight right now,” says @ScottGottliebMD. “The bottom line is we have an overwhelming toolbox right now to combat COVID.” pic.twitter.com/8qxwj73GBf

— Squawk Box (@SquawkCNBC) November 5, 2021

“We have an overwhelming toolbox right now to combat COVID,” he says, which is true — prospectively. But Pfizer will be capable of crank out “only” 180,000 pill packs by the end of the 12 months and is aiming for not less than 21 million packs in the first six months of subsequent 12 months. That’s progress, however America continues to be averaging greater than 80,000 instances per day. The capsules must be reserved at first for the aged and people with severe comorbidities since there received’t be sufficient to go round.

Should being unvaccinated rely as a comorbidity in assessing excessive threat? Will the unvaccinated even need a extremely efficient therapeutic from the similar firm that manufactures the demon vaccine? We’re about to have one other nationwide argument about how scarce care must be rationed in the age of COVID.

On the flip facet, will Biden stick along with his divisive federal vaccine mandate in January if Pfizer’s and Merck’s medicine are on the market, serving to to reduce extreme sickness in the contaminated on the again end?

It’s attainable that we received’t want an enormous stockpile of paxlovid this winter. Some scientists (like Gottlieb) imagine that we’ve seen our final main wave of COVID. Note, nevertheless, that Germany’s presently experiencing one of its worst waves of the pandemic and they’ve the next vaccination price than we do. Maybe we’ve got extra pure immunity in the inhabitants right here to restrict the unfold, but when not, we’d not be carried out with waves in any case. Quick regulatory approval of Pfizer’s drug by the FDA and an all-out effort to enlist spare manufacturing to flood the market must be high precedence for the feds.



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Home Tags:covid, cuts, deaths, highrisk, Hospitalizations, HotAir, Pandemic, People, Pfizers, Pill

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